Bladder dysfunction changes from underactive to overactive after experimental traumatic brain injury.:

Bladder dysfunction changes from underactive to overactive after experimental traumatic brain injury.
Exp Neurol. 2012 Nov 21;
Authors: Jiang HH, Kokiko-Cochran ON, Li K, Balog B, Lin CY, Damaser MS, Lin V, Cheng JY, Lee YS
Abstract

Although bladder dysfunction is common after traumatic brain injury (TBI), few studies have investigated resultant bladder changes and the detailed relationship between TBI and bladder dysfunction. The goal of this study was to characterize the effects of TBI on bladder function in an animal model. Fluid-percussion injury was used to create an animal model with moderate TBI. Female Sprague-Dawley rats underwent TBI, sham TBI or were not manipulated (naïve). All rats underwent filling cystometry while bladder pressure and external urethral sphincter electromyograms were simultaneously recorded 1day, 1week, 2weeks, and 1month after injury. One day after injury, 70% of the animals in the TBI group and 29% of the animals in the sham TBI group showed no bursting activity during urination. Compared to naïve rats, bladder function was mainly altered 1day and 1week after sham TBI, suggesting the craniotomy procedure affected bladder function mostly in a temporary manner. Compared to either naïve or sham TBI, bladder weight was significantly increased 1month after TBI and collagen in the bladder wall was increased. Bladder function in the TBI group went from atonic 1day post-TBI to overactive 1month post-TBI, suggesting that TBI significantly affected bladder function.

PMID: 23178579 [PubMed – as supplied by publisher]